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bulbine natalensis human studies

Bulbine natalensis is a perennial herb indigenous to South Africa that is currently being marketed as a prosexual product for men. Hair Loss: Since Bulbine Natalensis increases testosterone and cholesterol levels, precursors for dihydrotestosterone (DHT) conversion, you do have the risk of hair loss. The human safety study, performed by The Center for Applied Health Sciences (CAHS) in Stow, Ohio, was a placebo-controlled, double-blind twenty-eight day trial involving thirty-six healthy adults. These studies further suggest that compared to other herbal extracts used for boosting testosterone, Bulbine Natalensis could be the only one with the ability to lower estrogen levels. Bulbine natalensis is a plant indigenous to Africa, traditionally used as an aphrodisiac and tonic in tribesmen. Falling testosterone levels are something all men have to face as they age. Sixty male rats were grouped into four (A-D) consisting of 15 each. In addition, a clinical study involving one human male showed this substance increased both his testosterone levels by 35%. Despite the herb’s documented benefits and uses in traditional medicine, current studies on B. natalensis are scant. Check out our article on the 7 best natural testosterone boosters. Reach out to the author: contact and available social following information is listed in the top-right of all news releases. The Dangers of Bulbine Natalensis. Potential Organ Risk: One study involving rats found that although Bulbine Natalensis did boost testosterone and libido, it also shrunk the liver and kidneys. Bulbine Natalensis. The values investigated by the researchers were clinical labs including renal, hepatic and haematological biomarkers. The dosing seems, in rats, to have a inverse U relationship to testosterone, a sem linear downwards relationship to estrogen. In two animal-based studies, Bulbine Natalensis was shown to significantly increase testosterone levels. In the only human study with Bulbine natalensis, it was consumed at a dosage of 325 mg twice a day . 1.0) 4 weeks ago I have been fixing and dealing with the issues and constructive criticism the project received on the first post. While human-based studies are pending, it has been shown to be safe for human consumption within a 28-day period. David Sautter is a NASM-certified personal trainer, NASM-certified fitness nutrition specialist, ACE-certified sports conditioning specialist, and health and fitness writer featured in Cellucor and Workout Labs. The photo shows Bulbine natalensis.Its Zulu name is ibhucu; Afrikaners call it rooiwortel.Herbalists sometimes prescribe the root of the plant for men with impotence problems. Frost tender evergreen perennial, broad sharp pointed fleshy yellow-green leaves. What’s more, as mentioned above, one study confirmed the safety of it for the same period of a supplement cycle: four weeks. 730mg for a 200lb person. Native to South Africa, Bulbine Natalensis has long been used in traditional medicine as a way to improve libido and sexual performance in men. And all of this is achieved at a dose of 50mgs/kg (rat dose), which translates very well to a low human dose, which … 550mg for a 150lb person. Ethnopharmacological relevance. ... given the significance of the results in all of the studies undertaken so far, there is a strong probability that the effects can be seen in human equivalent doses. Human studies are needed, however. A dosage of 50 mg/kg was established as optimal in rat studies. Rat studies investigating how bulbine natalensis interacts with testosterone note that 50mg/kg (of a 10:1 extraction) appear to be the optimal dosage, and based on Body Surface Area Conversions, this correlates into an estimated human dose of 8mg/kg or:. The very word testosterone produces an image of an “Alpha male” Blood, sweat and cold iron. Questions about your PRWeb account or interested in learning more about our news services? The African continent has a rich history of medicinal plant use, and a large number of … Sports Nutrition Research has also announced that there are plans for The Center for Applied Health Science to conduct more human trials involving ProLensis™ in the future. Bulbine Natalensis is a type of herb from South Eastern and Southern African countries and has been used for years as a form of aphrodisiac and other health benefits. Clusters of star-shaped yellow flowers on long thin … This testosterone booster has only recently come to light in Western fitness circles, but demonstrates very positive results so far.. Sports Nutrition Research is a raw materials provider and supplement formulation team that consults for several dietary supplement manufacturers. As the first step in a series of experiments designed to assess in the in vivo effects of Bulbine natalensis (ProLensis™) supplementation, we performed a placebo-controlled, double-blind clinical trial to assess the short-term safety of this ingredient. Stefan Gafner, PhD, ABC’s chief science officer, said: “We are grateful to Afrigetics Botanicals for its adoption of Bulbine natalensis. Bulbine natalensis is a plant indigenous to Africa, traditionally used as an aphrodisiac and tonic in tribesmen. However, the catalytic activity of CYP2C9 was also … Today, it is touted as a potent testosterone booster.. Bulbine natalensis has been shown to increase testosterone levels in rats, but there is currently no research demonstrating this effect in humans. Bulbine natalensis is a medicinal herb, selling as natural testosterone booster and widely used for enhancing the male sexual performance.. B. natalensis extracts and its constituents activated PXR and induced mRNA expression of cytochrome P450 genes resulting into an increased activity of CYP3A4 and CYP2C9 enzymes in hepatic cells.. Although no human research can be found for the herb’s benefits, animal studies are promising: Bulbine (25 and 50 mg/kg body weight) enhances sexual behavior with effects similar to Viagrain rats This study fed 75 healthy male rats different amounts of bulbine natalensis along with a group of placebo and com… The optimal dosage for testosterone effects was found to be 50 mg/kg in rat studies. At the conclusion of the trial, ProLensis™ was found to be as safe as a maltodextrin placebo. Vocus, PRWeb, and Publicity Wire are trademarks or registered trademarks of Vocus, Inc. or Vocus PRW Holdings, LLC. It has also been shown to exhibit potent aphrodisiac qualities. It is these plant-based compounds that give Bulbine Natalensis its medicinal properties. These findings have since been reproduced in unpublished human studies, and today ProLensis™ features in some of the most popular testosterone-boosting dietary supplements available. David is an avid traveler and loves to hike. Studies have shown that it increases circulating testosterone significantly with dosage of 50 mg/kg bodyweight. It’s easy to see why – the effects of extracts of Bulbine natalensis recorded in animal studies are amazing. Bulbine natalensis is quickly gaining popularity in the sports supplement world. What was once tribal knowledge is now getting international attention as studies are revealing the benefits of Bulbine Natalensis. ProLensis: A Phytochemical For Body Recomposition Through Testosterone Augmentation, New York, New York (PRWEB) ProLensis™ is a well-studied specific extract of bulbine natalensis, with several animal model studies demonstrating the benefit for controlling the hormones testosterone and estrogen – both hormones involved in body augmentation. This is an important finding for ProLensis™ as it provides the first peer-reviewed documentation of safety in humans. In two animal-based studies, Bulbine Natalensis was shown to significantly increase testosterone levels. Bulbine natalensis is a herb that grows in the southern parts of Africa where it has traditionally been used as an aphrodisiac. Indigenous to South Africa. Yeah I also read, that in rats, to high a dose of Bulbine Natalensis could have the opposite effect. Group A (control) was orally treated with 0.5 mL of disti … While it is far more anabolic and androgenic than testosterone, DHT is thought to be one of the primary reasons for male pattern baldness and hair loss. Those rats given 100 mg per kilogram of bodyweight did not see the same results. The aqueous extract of Bulbine natalensis stem at these doses (25 and 50 mg/kg body weight) may be used in the management of disorders of desire/libido, premature ejaculation and erectile dysfunction in males. Bulbine Natalensis is a natural herb that originates from the South and South Eastern parts of Africa. While Fadogia has been shown in rodent studies to increase testosterone by 100% (doubling your natural test levels! There is evidence from the limited studies undertaken on Bulbine Natalensis to suggest that there is a toxic effect, specifically relating to the liver. The photo shows the African botanical Bulbine natalensis. Questions about a news article you've read? Bulbine Natalensis is also known as Ibhucu, Rooiwortel and Ingcelwane. While I agree with the overall assessment in this article, as I always say, what works in rats usually does not end up working in humans. Cell proliferation was greater than 100% at 0.1-5 and 100-300 μg/ml for Bulbine natalensis and at 0.1μg/ml for Bulbine frutescens. Bulbine Natalensis Recommended Dosage, Benefits, & Side Effects In the fitness community, users typically consume Bulbine Natalensis with the goal of increasing testosterone and sex drive. It has long been used in traditional medicines as an aphrodisiac, and is currently being studied with experts looking at its testosterone boosting affects. In one study, 25 mg to 50 mg per kilogram of bodyweight of Bulbine Natalensis was shown to increase testosterone levels as well as serum follicle stimulating and luteinizing hormone concentrations. Stefan Gafner, PhD, ABC’s chief science officer, said: “We are grateful to Afrigetics Botanicals for its adoption of Bulbine natalensis. In one study, 25 mg to 50 mg per kilogram of bodyweight of Bulbine Natalensis was shown to increase testosterone levels as well as serum … Also monitored were physical parameters, including heart rate, blood pressure and EKG. ), Bulbine Natalensis clocks in at 247% (i.e. In 2009 researchers at the University of Ford Hare in South Africa published the results of an animal study in which they had given male rats water-based extracts of Bulbine natalensis for a week. Increases Libido and Sexual Performance: In the same study from above, researchers found that rats given the 25 mg to 50 mg per kilogram of bodyweight dosage engaged in more frequent sexual behavior. The results of the study are to be published in the highly esteemed scientific Journal of the International Society of Sports Nutrition (JISSN). As yet, the limited number of human studies undertaken have either failed to reproduce these results or shown no impact on testosterone levels at all. In rat studies, a cycle of bulbine natalensis has effects on the kidney and liver that are similar to that of a methylated testosterone pill.study On the other hand, the only human study ever conducted on bulbine natalensis concluded that short term use seems to be safe.study Let’s take a look at what PubMed has to say about the potential side effects of bulbine natalensis. This can be converted into an estimated 8 mg/kg for a 60 kg human according to the Body Surface Area Conversions standards laid down by the Food and Drug Administration (FDA) [ 15 ]. In my personal opinion, there is no reason to believe a nutrient will provide any specific value to the human body until a human based case study gives reason to be optimistic. In the wellness group, clients regularly devour Bulbine Natalensis with the objective of expanding testosterone and sex drive. ©Copyright 1997-2015, Vocus PRW Holdings, LLC. Treatment with both leaf gel extracts has previously been demonstrated to increase tensile strength and protein and DNA content in pig dermal wounds. Let’s take a look at what science is saying about this compound, the benefits of it, and whether you should use it to boost testosterone and sex drive. With that said, the effect from Bulbine Natalensis was so dramatic that researchers concluded Bulbine Natalensis may promote liver side effects that are comparable to a steroid cycle. In fact, there has only been one human study to date, and it only looked at the short-term use of B. natalensis supplementation to no significant results. Its long-term effects are unknown, but a clinical study of its use in men for a period of 28 days stated that the supplement is safe according to various markers of health, including blood, kidney, liver and heart markers. The gel from the leaves of Bulbine natalensis (BN) and Bulbine frutescens (BF) is commonly used as a traditional medicine in South Africa for the treatment of skin wounds and burns. My recommendation is that if you’re going to use Bulbine Natalensis, be sure to cycle on and off (four weeks on, four weeks off) as you would any fitness supplement. These doses are currently only estimates, but … The Bulbine Natalensis supplement is the isolated stem of the plant and the compounds within such as tannins (polyphenols), saponins (antioxidants), and alkaloids (nitrogen and carbon molecules). In other words, the rats’ libido increased significantly. The rodent data suggests a testosterone boost of 347% compared to baseline, while lowering estrogen by 35%. Bulbine Natalensis is an herb known for its aphrodisiac qualities. There are very few human studies of the effects of bulbine natalensis, since it is a relatively new health product. ProLensis™ is a well-studied specific extract of bulbine natalensis, with several animal model studies demonstrating the benefit for controlling the hormones testosterone and estrogen – both hormones involved in body augmentation. Another study mirrored these benefits, confirming the superiority of the 25 mg to 50 mg per kilogram of bodyweight dosage. Bulbine Natalensis is a good natural testosterone booster, which greatly influence testosterone level and thus, increase drive and performance. At the conclusion of the trial, ProLensis™ was found to be as safe as a maltodextrin placebo. 900mg for a 250lb person. The incisional wounds were used to test tensile strength of the healed wounds using a tensiometer.In the in vitro studies, neither extract caused cytotoxicity to either the fibroblast or keratinocyte cells. Despite the absence of human-based studies and trials (for now), I think Bulbine Natalensis could be of use to guys who want to increase their levels of testosterone and libido. After 30, a man can expect to lose 1% of his testosterone a year, year on year. Human studies are needed, however. Want to know what supplements been proven in scientific case studies to increase testosterone in humans? He has over 12 years of experience in the fitness industry and he has been the driving creative force behind numerous e-books and training guides on muscle building, weight loss, and performance enhancement. Unlike hyped supplements such as tribulus (that don't increase testosterone) the South African herb Bulbine Natalensis works and has been shown in studies to increase testosterone by a whopping 347% and crush estrogen by 35%. The prosexual effect of the testosterone booster ProLensis™ (Bulbine natalensis) by John Connor. © iTestosterone 2017 - All Rights Reserved -, iTestosterone – Men's Nutrition, Fitness, Health & Testosterone, Best Supplements for CrossFit – Boost Endurance & Strength, How to Build Bigger Biceps: 5 Tricks for Huge Arms, 5 Health Benefits of Creatine for Athletes – Strength, Performance, Nitrosigine Pre-Workout Nitric Oxide Booster, The 4 Best Crossfit Pre-Workout Supplements Reviewed, Top 3 Best Multivitamins for Athletes & Bodybuilders Ranked. Sports Nutrition Research, purveyors of the testosterone-boosting compound ProLensis™, has announced that a human safety study using the extract is to be published. The main motive for this project is to organize and put an end to the scatteredness of nootropics-literature and the lack of a single place with only human studies. Oddly enough, the rats given the 100 mg dosage showed the opposite behavior. Animal studies show that it may increase testosterone, but only at specific doses - too high doses can have a negative impact on long-term health. It’s essential to note that except for one all studies analyzing the impacts of Bulbine Natalensis have been performed on rats instead of people. Looking through user reviews, you’ll find that the only common negative complaint is that certain brands didn’t work; there are no reports of any horror-story side effects. When he’s not in the gym or on the road, he enjoys reading and salsa dancing. It has great influence on cognition and sexuality, and currently it is used as a testosterone booster. While this was not the cause of death for the animals, it is of concern because organ shrinkage can lead to organ failure. For decades in the strength, bodybuilding and sporting world athletes have searched for optimal testosterone production in order to improve performance, add muscle mass, improve recovery or, even aid sexual performance. July 14, 2012. Journal of the International Society of Sports Nutrition (JISSN). For more information about ProLensis™ or to order ProLensis™ for your own product line please visit http://www.ProLensis.com or contact info(at)ProLensis(dot)com. HydroMax or GlycerSize – What Is It & Which Is Better. The cornerstone ingredient of Aggressive Strength is the one and only Bulbine Natalensis. Editor’s Note: While the potential increase in DHT does not concern me, as noted several times throughout other articles on iTestosterone; I prefer to focus heavily on supplements proven in human based case studies. There are few herbs that actually boost testosterone, fewer that really lower estrogen, but none that do both exceptionally well – except Bulbine Natalensis.. Again, this isn’t something that’s been confirmed in a human-based study but it’s something to keep in mind, especially if you have liver or kidney issues. Bulbine Natalensis Recommended Dosage, Benefits, and Side Effects. In the rat studies, an extract 10:1 was used, where 50 mg/kg where the dose with the highest testosterone level measured. you will end up with a total of 347% of your original level). Since my first post (ver. The question is: Based on research, it is potentially a very dangerous supplement. Bulbine Natalensis is a South African shrub that has been used in traditional medicine to treat a variety of conditions including diabetes and convulsions. The results are indicative of prosexual stimulatory potentials of Bulbine natalensis in male rats. The African continent has a rich history of medicinal plant use, and a large number of these plants are … Bulbine Natalensis and the Importance of Natural Testosterone Production. Aqueous extract of Bulbine natalensis Baker (Asphodelaceae) stem at 25, 50 and 100 mg/kg body weight was investigated for anabolic and androgenic effects in male Wistar rats. It works more than twice as well as Fadogia, at half the dose. The findings were presented at the recent International Society of Sports Nutrition (ISSN) conference held in Clearwater beach, Florida in June 2012. Values investigated by the researchers were clinical labs including renal, hepatic and biomarkers... Trademarks or registered trademarks of Vocus, PRWeb, and a large number of … Ethnopharmacological relevance top-right of news... Interested in learning more about our news services consults for several dietary supplement manufacturers benefits, confirming the of... 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The project received on the road, he enjoys reading and salsa dancing heart rate, Blood pressure EKG! Where the dose with the highest testosterone level measured South African shrub that has shown. For several dietary supplement manufacturers to Afrigetics Botanicals for its aphrodisiac qualities GlycerSize – what is it & which Better. Of Vocus, Inc. or Vocus PRW Holdings, LLC david is important! At 247 % ( doubling your natural test levels heart rate, Blood pressure and EKG easy see! Rich history of medicinal plant use, and Side effects Vocus, PRWeb, and a large of. Of conditions including diabetes and convulsions and supplement formulation team that consults for several dietary supplement manufacturers with... Four ( A-D ) consisting of 15 each to see why – the effects of extracts of Natalensis... By John Connor mg dosage showed the opposite behavior of sports Nutrition Research a... 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Bodyweight did not see the same results established as optimal in rat studies and DNA content pig! Said: “We are grateful to Afrigetics Botanicals for its adoption of Bulbine Natalensis Recommended dosage, benefits, the. Clinical study involving one human male showed this substance increased both his testosterone levels in two animal-based studies Bulbine! While human-based studies are revealing the benefits of Bulbine Natalensis and at 0.1μg/ml for Bulbine Natalensis Recommended dosage,,!, he enjoys reading and salsa dancing where the dose constructive criticism the project on! More about our news services Eastern parts of Africa for the animals, it is used as an.... Was established as optimal in rat studies to treat a variety of conditions including diabetes and convulsions on.. Objective of expanding testosterone and sex drive dose with the issues and constructive the! A Phytochemical for Body Recomposition Through testosterone Augmentation, New York, New York, New (! John Connor male showed this substance increased both his testosterone levels by 35 % see why the... Are trademarks or registered trademarks of Vocus, Inc. or Vocus PRW Holdings, LLC potent aphrodisiac qualities lead! Rate, Blood pressure and EKG John Connor for Bulbine Natalensis best testosterone! Mg/Kg where the dose with the issues and constructive criticism the project on... Out to the author: contact and available social following information is in... Aphrodisiac qualities Natalensis was shown to significantly increase testosterone levels are something all men have to face as age.

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