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nucleic acid metabolism ppt slideshare

After reading this article you will learn about 1. DNA • Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms. Nucleic acids are polymers of nucleotides. nucleic acid ppt 1. organic molecules. METABOLISM Naresh panigrahi Gitam university Nucleic Acid. See our Privacy Policy and User Agreement for details. In addition to these direct effects, alterations in the metabolism of proteins or nucleic acids may be consequent to the effect of the drug on other metabolic processes such as transport or energy supply. The third base of each codon (in bold type) plays a lesser role in specifying an amino acid than the first two. All the amino acids except methionine and tryptophan have more than one codon. Digestion and Absorption of Nucleic Acid and 2. 2. 3. Hypouricemia 5. For nucleic acid biosynthesis, which is energetically costly, the nucleotide synthesis consumes 0.5–9 pmol exogenous carbon, which is comparable in number to the ATP hydrolysis. The Nucleic acid stability of the native state is based on the magnitude of the Gibbs free energy (∆G) of the system and the thermodynamic relationships between enthalpy (∆H) and entropy (∆S) changes. Errors in Nucleic Acid Metabolism: Disease # 1. They are the hereditary determinants of living organisms. ADVERTISEMENTS: The following points highlight the six major diseases caused due to errors in nucleic acid metabolism. In most cases, codons that specify the same amino acid differ only at the third base. Illustrate structure of nucleotides. This is the power point presentation by Emma271 a Biotechnology student in JSS University 2014 in his second year. Objectives By the end of lecture the student should: Define nucleic acids. Metabolism of nucleic acids (4) Antagonists of deoxy- nucleotide biosynthesis (4) Antagonists of deoxy- nucleotide biosynthesis 3. Disorders of nucleic acid metabolism- hyperuricemia,hypouricemia,gout Clipping is a handy way to collect important slides you want to go back to later. Nucleic acids are the biomolecules that are essential for every form of life present on the earth. Nucleotide synthesis is ananabolic mechanism generally involving the chemical reaction of phosphate, pentose sugar, and a nitrogenous base. Hereditary Xanthinuria 3. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. The text is divided in two parts. In this early world, RNA was the predominant macromolecule. Structures of Nucleic Acids labels in biology.) NATs have several advantages over other diagnostic tools, including rapid turnaround time, the ability to detect low levels of all known pathogens, the lack of dependence on the viability of the target microorganism, little influence of antimicrobial therapy on diagnostic sensitivity, and the ability to be automated. In other meaning, this disease is the severe scarring of the liver and the poor liver function will show at the terminal stages of the chronic liver disease because it's often caused by the long-term exposure to the toxin such as alcohol or vital infection. Genes are made of DNA, a nucleic acid. Part 2. The nucleus is surrounded by a nuclear envelope, two membrane bilayers Molecules come into and out of the nucleus through nuclear pores The inside of the nucleus is called the nucleoplasm. Nucleotide Metabolism: An Introduction is a textbook exclusively focusing on the study of the aspects of nucleotide metabolism. The word nucleic acid is used collectively for DNA and RNA. Orotic Aciduria 4. This condition is characterized by the […] 4. Thus, to make nucleic acids for cell proliferation purposes, cells have to upregulate both energy metabolism and the nucleotide biosynthetic pathways. They are present in all organisms from small viruses and bacteria to large and complex animals like humans and whales. "Dictionary" of amino acid code words in mRNAs. A nucleic acid in aqueous solution is in equilibrium between the native conformation and its uncoiled conformation. The Amino Acid Sequence Of A Polypeptide Is Programmed By A 942583 PPT Presentation Summary : The amino acid sequence of a polypeptide is programmed by a unit of inheritance called a gene. Nucleotide synthesis is an anabolic mechanism generally involving the chemical reaction of phosphate, pentose sugar, and a nitrogenous base. See our User Agreement and Privacy Policy. Chromatin is the name given to DNA complexed with proteins (histones) The nucleolus is a region where the DNA is concentrated for … 2.1, The proteins of T2 phage were labeled with 35S (e.g. Date : 27 September 2014. Now customize the name of a clipboard to store your clips. Nucleotides and Nucleic Acids Chapter 8 Lehninger 5th ed. Structure of Nucleic Acids. 1. 1 Chapter 15 Lecture Notes: Metabolism Educational Goals 1. Presentation Summary : Nucleotide Metabolism. Are the largest and the most complex We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. If you continue browsing the site, you agree to the use of cookies on this website. Nucleotide Metabolism • Purine de novo Metabolism Summary Nucleotides are the Building Blocks of Nucleic Acids Nucleotide Metabolism Proceeds Through de novo and Salvage Pathways Purine Nucleotides are Built de novo Starting with Ribose-5-phosphate PRPP is … Errors that creep in during replication or because of damage after replication must be repaired. Deoxyribonucleic acid (DNA) encodes the information the cell needs to make proteins. Reye’s Syndrome. The metabolic requirements for the nucleotides and their cognate bases can be met by both dietary intake or synthesis de novo from low molecular weight precursors.Indeed, the ability to salvage nucleotides from sources within the body alleviates any significant nutritional requirement for nucleotides, thus the purine and pyrimidine bases are not required in the diet. Destruction of nucleic acid is a catabolic reaction. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. NUCLEIC ACIDS Nucleic acids and nucleotides methabolism, Ivano-Frankivsk National Medical University (IFNMU), Biomolecular ligand-receptor-binding-studies-theory, No public clipboards found for this slide. Nucleic Acid Analysis. Looks like you’ve clipped this slide to already. Friedrich Miescher • They are present in most living cells either in free state or Nucleic Acid Metabolism Nucleotides Essential for all cells Carriers of activated intermediates in carbohydrate, lipids and proteins CoA FAD NAD NADP – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 3d0ba4-YWQ5N • most nucleic acids in the cell are associated with protein • dietary nucleoprotein is degraded by pancreatic enzymes and tissue nucleoprotein by lysosomal enzymes • after dissociation of the protein and nucleic acid, the protein is metabolized like any other protein • the nucleic acids are hydrolyzed randomly by nucleases to yield a 8. The diseases are: 1. NUCLEIC ACID • Nucleic acid are polymers that consist of nucleotide residues. Clipping is a handy way to collect important slides you want to go back to later. – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 60853b-Nzg4N The nucleus contains the cell’s DNA, which makes up the genome. If you continue browsing the site, you agree to the use of cookies on this website. Nucleic acid metabolism Nucleic acid metabolism is the process by whichnucleic acids (DNA and RNA) are synthesized and degraded. who discovered nucleic acids in 1871. Subject: Biochemistry Topic : Nucleic acids Catabolism of Nucleosides. Nucleic acids are the most important macromolecules for the continuity of life.They carry the genetic blueprint of a cell and carry instructions for the functioning of the cell. DNA must be replicated accurately in order to ensure the integrity of the genetic code. THE NUCLEIC ACIDS MEENAKSHY SUDEEP 2. For example, they are: • Substrates (building blocks) for nucleic acid biosynthesis and repair, • The main storage form of “high energy phosphate”, • Components of many “so-called” co-enzymes (NAD, NADP, FAD, CoA), • Components of many activated metabolic intermediates (such as UDPG, SAM), Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Von Gierke’s Disease 6. Nucleic acid, naturally occurring chemical compound that is capable of being broken down to yield phosphoric acid, sugars, and a mixture of organic bases (purines and pyrimidines).Nucleic acids are the main information-carrying molecules of the cell, and, by directing the process of protein synthesis, they determine the inherited characteristics of every living thing. Additionally, parts of the nucleotides or nucleobases can be salvaged to recreate … Nucleic acid metabolism is the process by which nucleic acids are synthesized and degraded. NUCLEOTIDE METABOLISM Mark Rush Nucleotides serve various metabolic functions. They are made up of repetitive subunits called nucleotides. You can change your ad preferences anytime. Now customize the name of a clipboard to store your clips. See our Privacy Policy and User Agreement for details. Let us make an in-depth study of the nucleic acid metabolism. Digestion and Absorption of Nucleic Acid: Nucleic acids are consumed in … As diagrammed in Fig. Nucleic acid - Nucleic acid - Nucleic acid metabolism: Replication, repair, and recombination—the three main processes of DNA metabolism—are carried out by specialized machinery within the cell. The RNA world is a hypothetical early stage of evolution. Define the terms metabolism, metabolic pathway, catabolism, and anabolism. Lesch-Nyhan Syndrome: a. Working with Molecular Genetics Chapter 2. The two nucleic acids differ i… Definition • Nucleic acids are essential large biological molecules for all forms of life. Nucleic acid is an important class of macromolecules found in all cells and viruses. Nucleic acid metabolic disorder - GOUT, Xanthinuria, Oratic aciduria NUCLEIC ACIDS AND THEIR. 1. in methionine and cysteine) and the DNA was labeled with 32P (in the sugar-phosphate backbone, as … The codons are written in the 5′→3′ direction. Nucleic Acids By: Gianna, Alex, and Gabriel THE END Body parts or plant parts where Nucleic Acids Can be found Human They are found in human DNA and RNA Polymers Plant Deoxyribonucleic Acid Also known as DNA holds the information on all the characteristics of your body there are HISTORIC RESUME Friedrich Miescher in 1869 • Isolated what he called nuclein from the nuclei of pus cells • Nuclein was shown to have acidic properties, hence it became called nucleic acid 3. Understand the roles of the NAD +/NADH and FAD/FADH 2 Nucleic acids range in size from small biomolecules to large biopolymers. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The three termination codons are shaded in pink, the initiation codon AUG in green. 08/03/58 3 ชนิดของ Nucleic acid สามารถแบ่ง nucleic acid ได้ 2 ชนิด ตามชนิดของน ้าตาล C 5 ที่เป็นองค์ประกอบคือ 1. Nucleic Acid Chemistry Dr: Hussein abdelaziz. You continue browsing the site, you agree to the use of cookies on this.! In-Depth study of the liver acids range in size from small biomolecules to large.! Lehninger 5th ed understand the roles of the liver energy metabolism and the RNA in size from small to... Cookies on this website synthesized and degraded and activity data to personalize ads and to provide with... ้าตาล C 5 ที่เป็นองค์ประกอบคือ 1 of cookies on this website Structure of nucleic acids ( 4 ) of. Between the native conformation and its uncoiled conformation relevant advertising in JSS University in... 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