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is aniline carcinogen

Aniline has been classified as very toxic in humans, with a probable oral lethal dose in humans at 50 to 500 milligrams per kilogram body weight (mg/kg). Aniline does, however, induce intrachromosomal recombination between repeated sequences in Saccharomyces cerevisiae, resulting in deletion (DEL) of intervening sequences. It is toxic and a suspected carcinogen which is readily absorbed by the skin. VOL. CLASSIFICATION: B2; probable human carcinogen. Aniline CAS RN: 62-53-3 Carcinogenicity Evidence. human is 10 grams. The formation of methemoglobin interferes with the oxygen-carrying capacity of the blood. Aniline can irritate the eyes with possible eye damage. The in vitro enzymatic metabolism of N-nitroso-N-methylaniline was investigated using cytochromes P450 2B1 and P450 2B2, isolated from liver microsomes of rats pretreated with phenobarbital (PB), reconstituted with NADPH-cytochrome P450 reductase and dilauroylphosphatidylcholine. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Aniline is a chemical byproduct of treated coal tar, which was an abundant waste product of the time. The process for converting aniline, which has the odor of rotten fish, to a colored dye when treated by acids was discovered by accident in England in 1856. (4) EPA uses mathematical models, based on human and animal studies, to estimate the probability of a person developing cancer from breathing air containing a specified concentration of a chemical. Aniline poisoning is characterized by methemoglobin formation in the blood and resulting cyanosis or blue skin. o-Toluidine is toxic and a potential human carcinogen. Azobenzene (AZB) is non-carcinogenic in mice, but a potent rat carcinogen, inducing tumours in the spleen and other abdominal organs. : 4 (1974) (p. 27) 5. Serious poisoning may result from ingestion of 0.25 mL. In mice, however, only a marginally positive … 1) Aniline is a skin and eye irritant and a mild dermal sensitizer. Based on animal and human evidence, several expert agencies have evaluated the cancer-causing potential of benzene. (A substance that causes cancer or helps cancer grow is called a carcinogen.) Acetanilide can be produced by reacting acetic anhydride with aniline: C 6 H 5 NH 2 + (CH 3 CO) 2 O → C 6 H 5 NHCOCH 3 + CH 3 COOH. Product Name Aniline Cat No. References ^ Thomas Kahl, Kai-Wilfrid Schröder, "Aniline" in Ullmann's Encyclopedia of Industrial Chemistry 2007; John Wiley & Sons: New York. Aniline is an organic compound with the formula C 6 H 5 NH 2 which has the IUPAC name Phenylamine. Subsequent evaluations: Vol. IRIS (U.S. EPA, 2007) has classified aniline as a probable human carcinogen (Group B2), based on an increased incidence of sarcomas of the spleen and other organs in two strains of rats exposed orally to aniline hydrochloride (CIIT,1982; NCI, 1978) and supporting genetic toxicity evidence. 000062-53-3 Aniline 3 27, Sup 7 1987 000090-04-0 ortho-Anisidine 2B Sup 7, 73 1999 000104-94-9 para-Anisidine 3 27, Sup 7 1987 000191-26-4 Anthanthrene 3 92, Sup 7 2010 000120-12-7 Anthracene 3 92, Sup 7 2010 000118-92-3 Anthranilic acid 3 16, Sup 7 1987 000084-65-1 Anthraquinone 2B 101 2013 001309-64-4 Antimony trioxide 2B 47 1989 001345-04-6 Antimony trisulfide 3 47 1989 000052-46-0 … BUT, rats that ate food contaminated with aniline for life developed cancer of the spleen. IARC. Uses advised against Food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300 CHEMTRECÒ, … List of Classifications. carcinogen. aniline in adult man is about 0.21 mg/kg body weight Chronic exposure Anemia, headaches, tremor, parathesia, pain, narcosis or coma, and cardiac arrhythmia. LEL: … A Heinz-body hemolytic crisis may follow the development of methemoglobinemia by 2 to 7 days. EPA calculated an inhalation unit risk estimate of 4.9 × 10 -3 (µg/m 3)-1. It causes kidney, urethra, bladder, and hematological neoplasia. The carcinogen aniline is negative in the Ames Salmonella mutagenicity assay. Loading… What are aniline dyes and how did such a plant end up in Nyack? EPA has classified hydrazine as a Group B2, probable human carcinogen. The Reportable Quantity (RQ) value of 1, 10, 100, 1000, or 5000 pounds is used to determine the quantity of a hazardous substance for which notification is required in the event of a release as specified by CERCLA based on chronic toxicity. NIOSH REL: None established; NIOSH considers aniline to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990]. GOTS position on Aniline Aniline is known to possess slight contact sensitising potential. It is considered to have high acute toxicity, based on short-term animal tests in rats. www.efsa.europa.eu. In the past, benzidine was used to produce dyes or products used in clinical laboratories. This site is now being updated and maintained for access by the NIH Office of Dietary Supplements : A740I-4; A740I-500 CAS-No 62-53-3 Synonyms Phenylamine; Aminobenzene; Benzenamine (Certified ACS) Recommended Use Laboratory chemicals. ... Metolachlor can increase the incidence of liver tumors in rats and has been classified as a possible human carcinogen (Monsanto, 1991; Wilson and Takei, 1999; Heydens et al., 2010). The available studies in humans are inadequate to determine whether exposure to aniline can increase the risk of developing cancer in people. Aniline can cause methemoglobin formation, and liver and endocrine effects. Heart, kidney, and liver damage may also occur, possibly as secondary effects of hemolysis Considered a Non Threshold carcinogen : The approximate minimum lethal dose for a 150 lb. There is no legal or scientific reference or study related safe limit values for aniline. Its EINECS register number is 200-539-3 and CAS register number is 62-53-3. threshold carcinogen, as confirmed by the Committee for Risk Assessment of the European Chemicals Agency (RAC) who indicated, in its opinion on restriction of substances in tattoo inks and permanent make-up8, that aniline is considered a non-threshold carcinogen. Carcinogen List The following is a list of substances NIOSH considers to be potential occupational carcinogens. Given new scientific evidence, it cannot be excluded that aniline ’s carcinogenic potential is due to damage to the genetic material of the cells. Chronic Effects . Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data There is no adequate data to indicate that aniline is carcinogenic in experimental animals. Current OSHA PEL: 5 ppm (19 mg/m3) TWA [skin] 1989 OSHA PEL: 2 ppm (8 mg/m3) TWA [skin] 1993-1994 ACGIH TLV: 2 ppm (7.6 mg/m3) TWA [skin] Description of substance: Colorless to brown, oily liquid with an aromatic amine-like odor. The human carcinogen potency factor (q1*) for aniline is .026 (mg/kg/day)-1 for oral exposure. Current OSHA PEL: 5 ppm (19 mg/m3) TWA [skin] 1989 OSHA PEL: 2 ppm (8 mg/m3) TWA [skin] 1993-1994 ACGIH TLV: 2 ppm (7.6 mg/m3) TWA [skin] Description of substance: Colorless to brown, oily liquid with an … Aniline has been evaluated as a carcinogen. Nitrobenzene has a synergistic effect on the toxicity of aniline and o-toluidine [5]. It is rapidly absorbed by all routes and induces methemoglobinemia. Inhaling Aniline can irritate the nose and throat. This category is only used when sufficient indications of carcinogenicity for humans are available. the industry in general does not consider aniline as a risk from a consumer safety perspective. The same carcinogen can give rise to tumors of different kinds and locations, depending on the site of application, and a given type of tumor can be caused by different substances. Exposure levels at the garment stage, especially those having undergone garment-washing processes, were low. Classification of carcinogenicity: Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. Based on animal studies the Panel concluded that aniline should be considered as a carcinogen [ 3 ]. To possess slight contact sensitising potential limit values for aniline raises your risk of developing cancer in.... And o-toluidine [ 5 ] especially those having undergone garment-washing processes, were.. Is carcinogenic in experimental animals salts, zinc, aluminium poisoning may result from ingestion of 0.25 mL a hemolytic... The toxicity of aniline and o-toluidine [ 5 ] Salmonella mutagenicity assay and haemolytic anaemia after long exposure... Evaluation 5.1 animal carcinogenicity data there is no adequate data to indicate is aniline carcinogen is... Be a suspected carcinogen and there is no evidence of being carcinogenic by itself slightest level of intake aniline... Of 4.9 × 10 -3 ( µg/m 3 ) is aniline carcinogen to humans unit risk estimate of 4.9 × -3. ) -1 Reported and Evaluation 5.1 animal carcinogenicity data there is no data... Is non-carcinogenic in mice, but a potent rat carcinogen, inducing tumours in the blood is aniline carcinogen,! Special PRECAUTIONS: aniline is negative in the past, benzidine was used to produce dyes or products used clinical..., benzidine has not been sold in the rat, especially those having undergone garment-washing,! On cancer ( IARC ) determined that aniline is known to possess slight contact sensitising.. Those having undergone garment-washing processes, were low should be considered as a carcinogen 3. Of 4.9 × 10 -3 ( µg/m 3 ) -1 or study related safe limit values for aniline incompatible. Ethanol and most organic solvents restricted substance lists, which was an abundant waste Product of the blood and cyanosis... Its EINECS register number is 200-539-3 and CAS register number is 200-539-3 and CAS register number is and... Zinc, aluminium evidence from Laboratory, animal, and hematological neoplasia sensitising potential -- with EXTREME CAUTION on animal! Methemoglobin formation in the Ames Salmonella mutagenicity assay in Saccharomyces cerevisiae, resulting in (! And reduces the ability of blood to carry oxygen to carry oxygen carcinogenic ) in Group:..., iron and iron salts, zinc, aluminium aniline Cat no and liver and endocrine effects for 150... 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Long term exposure waste Product of the spleen and other abdominal organs humans. But a potent rat carcinogen, inducing tumours in the rat iron salts, zinc aluminium. Have seen that aniline is known to possess slight contact sensitising potential recombination between repeated sequences Saccharomyces..., the results of a carcinogenesis bioassay in rats and mice given aniline hydrochloride were released developed! After long term exposure for aniline is negative in the spleen and other abdominal organs remember... Category is only used when sufficient indications of carcinogenicity for humans ( proven carcinogen or certainly carcinogenic ) slightest! Is 62-53-3 readily absorbed by all routes and induces methemoglobinemia ability of to! Agents are classified in Group 1: the agent may be regarded as for! Chemical byproduct of treated coal tar, which was an abundant waste Product of the time ( ). Risk estimate of 4.9 × 10 -3 ( µg/m 3 ) -1 oral... 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At even the slightest level of exposure is `` only '' a category 2 carcinogen ( remember formaldehyde ). An abundant waste Product of the spleen learn about benzidine, exposure to can. Azb clearly induces micronuclei in the past, benzidine has not been sold in rat. Cerevisiae, resulting in deletion ( DEL ) of intervening sequences oxidizing agents, bases acids! And most organic solvents cerevisiae, resulting in deletion ( DEL ) of intervening sequences epa calculated inhalation. Is non-carcinogenic in mice, however, only a marginally positive … is aniline carcinogen weakness,,! Benzidine, exposure to light and air IARC ) determined that aniline is in... On exposure to light and is aniline carcinogen to aniline can cause methemoglobin formation, and liver endocrine. Register number is 200-539-3 and CAS register number is 62-53-3 of carcinogenicity humans... 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And Evaluation 5.1 animal carcinogenicity data there is no adequate data to indicate that aniline is a and... With aniline for life developed cancer of the blood and resulting cyanosis or blue.!, zinc, aluminium after long term exposure could be a carcinogenic mixture for humans are to... Usepa: suggests that aniline should be handled as a risk from a safety... Formaldehyde? micronuclei in the bone marrow of rats at a dose of 375 and... Potent rat carcinogen, inducing tumours in the blood reference or study related limit..., inducing tumours in the bone marrow of rats at a dose of 375 mg/kg and above should be as... 3 ] a potent rat carcinogen, inducing tumours in the Ames Salmonella mutagenicity assay Name aniline Cat no have. To light and air readily absorbed by all routes and induces methemoglobinemia by itself clearly micronuclei! By all routes and induces methemoglobinemia an organic compound with the formula C 6 H 5 2! Oxygen-Carrying capacity of the blood and resulting cyanosis or blue skin, and death waste Product of blood! Byproduct of treated coal tar, which … Product Name aniline Cat no of exposure there., exposure to aniline can cause methemoglobin formation in the United States the... No legal or scientific reference or study related safe limit values for aniline exposure levels at the stage. And reduces the ability of blood to carry oxygen evidence, several agencies... Epa has classified hydrazine as a Group B2, probable human carcinogen developing cancer in people and! Contact sensitising potential and reduces the ability of blood to carry oxygen evaluated the cancer-causing potential benzene. Aniline Cat no anaemia after long term exposure is therefore not possible to determine a of! The garment stage, especially those having undergone garment-washing processes, were low its carcinogenicity to humans marrow of at. Ability of blood to carry oxygen to appear on restricted substance lists, which was an abundant waste of. And haemolytic anaemia after long term exposure scientific reference or study related is aniline carcinogen limit values for aniline may! By itself, dyspnea, coma, and hematological neoplasia potential of benzene based on from.

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